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Tag: p38γ (Page 1 of 4)

EMBO e-talks: Stress kinases in cardiometabolic diseases (3 Nov 2021)

On Wednesday 3 Novmber 2021 al 14:00 (CET), Guadalupe Sabio will talk at an EMBO e-talk about the role of stress kinases in cardiometabolic diseases.

To attend the talk yu should register at the following link: https://embo-org.zoom.us/webinar/register/WN_ePJby4iNRbyj0oSxxtgDUQ

The p38 mitogen-activated kinase (MAPK) family controls cell adaptation to stress stimuli. There are four different p38 family members with different roles in relation to cardiac development and function.

The first isoform demonstrated to play an important role in cardiac development was p38α; however, all p38 family members are now known to collaborate in different aspects of cardiomyocyte differentiation and growth. p38 family members have been proposed to have protective and deleterious actions in the stressed myocardium, with the outcome of their action dependent on the model system under study and the identity of the p38 family member activated.

In this talk, we summarize current understanding of the role of the p38 pathway in cardiac physiology and discuss recent advances in the field.

Premio de Investigación Fundación Dr. Antoni Esteve 2021

El tribunal internacional que cada dos años concede el Premio de Investigación Fundación Dr. Antoni Esteve ha considerado nuestro artículo científico p38γ is essential for cell cycle progression and liver tumorigenesis como la publicación farmacológica más importante publicada por un autor español entre 2019 y 2020.

Premio de Investigación Fundación Dr. Antoni Esteve 2021

Además, han reconocido con una mención honorífica un trabajo del grupo de Rubén Nogueiras y Luisa Seoane, y cuya primera firmante, Cintia Folgueira se encuentra ahora en nuestro grupo de investigación.

Uncovering the role of p38 family members in adipose tissue physiology

Magdalena Leiva, Nuria Matesanz, Marta Pulgarín-Alfaro, Ivana Nikolić & Guadalupe Sabio.

The complex functions of adipose tissue have been a focus of research interest over the past twenty years. Adipose tissue is not only the main energy storage depot, but also one of the largest endocrine organs in the body and carries out crucial metabolic functions. Moreover, brown and beige adipose depots are major sites of energy expenditure through the activation of adaptive, non-shivering thermogenesis.

p38-mediated adipose tissue secretome
The p38-mediated adipose tissue secretome.

In recent years, numerous signaling molecules and pathways have emerged as critical regulators of adipose tissue, in both homeostasis and obesity-related disease. Among the best characterized are members of the p38 kinase family. The activity of these kinases has emerged as a key contributor to the biology of the white and brown adipose tissues, and their modulation could provide new therapeutic approaches against obesity.

Here, we give an overview of the roles of the distinct p38 family members in adipose tissue, focusing on their actions in adipogenesis, thermogenic activity, and secretory function.

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