Nuestra compañera Beatriz Cicuéndez reconoce que necesita «tener aficiones que la saquen del laboratorio porque investigar engancha».
Author: Sabio lab (Page 31 of 62)
Elena Hernández-García, Francisco J. Cueto, Emma C. L. Cook, Ana Redondo-Urzainqui, Sara Charro-Zanca, Iñaki Robles-Vera, Ruth Conde-Garrosa, Ivana Nikoli?, Guadalupe Sabio, David Sancho & Salvador Iborra.
Conventional dendritic cells (cDCs) scan and integrate environmental cues in almost every tissue, including exogenous metabolic signals. While cDCs are critical in maintaining immune balance, their role in preserving energy homeostasis is unclear.
Here, we showed that Batf3-deficient mice lacking conventional type 1 DCs (cDC1s) had increased body weight and adiposity during aging. This led to impaired energy expenditure and glucose tolerance, insulin resistance, dyslipidemia, and liver steatosis. cDC1 deficiency caused adipose tissue inflammation that was preceded by a paucity of NK1.1+ invariant NKT (iNKT) cells. Accordingly, among antigen-presenting cells, cDC1s exhibited notable induction of IFN-? production by iNKT cells, which plays a metabolically protective role in lean adipose tissue. Flt3L treatment, which expands the dendritic cell (DC) compartment, mitigated diet-induced obesity and hyperlipidemia in a Batf3-dependent manner. This effect was partially mediated by NK1.1+ cells.
These results reveal a new critical role for the cDC1-iNKT cell axis in the regulation of adipose tissue homeostasis.
We are seeking a highly motivated candidate, who would like to start a scientific career doing their doctoral thesis working in understanding the molecular mechanisms involved in how metabolic alterations can affect the cardiac disease, focusing on cardiac metabolism and how the rest of the organs affect it. This work will be supervised by Dr. Guadalupe Sabio.
We offer incorporation to CNIC via an FPU predoctoral contract (FPU 2021 call).
ELEGIBILITY CRITERIA
- This call is open to applicants from all nationalities holding a Master’s degree in Biomedical Sciences and an academic record with average grade over 8,7 (out of 10).
- An excellent academic record and previous research experience during their undergraduate period will be valued very positively.
- Authorship of publicacions in indexed journal will be valued very positively.
- Candidates must have a solid working knowledge of English.
If you are interested, please send your CV, academic record, a letter of interest and contact details of previous references to Laura Grau (lgrau@cnic.es) indicating in the subject: “FPU2021 Guadalupe Sabio’s lab” no later than December 7th 2021.
Interested candidates will also need to apply officially throught the official governmental application for this predoctoral program (additional information: FPU 2021 call ).
