Tag: lipid metabolism (Page 1 of 9)

Mediators in Interorgan Crosstalk (3-4 Nov 2025)

28/05/2025 / Sabio lab

The workshop Mediators in Interorgan Crosstalk will take place in Valencia on 3-4 November 2025. Guadalupe Sabio will participate in this meeting that will address the molecular basis of interorgan communication in patients, organoids, mouse, and cellular models, including sex-specific differences and therapeutic approaches.

The meeting is open and free of charge although you must register in advance through this form until June 30^th:

https://saco.csic.es/apps/forms/s/Qe32ync7QnPNG7eYE7dTYbWo

Energy balance in metabolic diseases (10-13 Feb 2025)

15/02/2025 / Sabio lab

We organized the EMBO Workshop Energy balance in metabolic diseases at Torremolinos (Spain).

The conference’s convened leading researchers to explore the complex mechanisms underlying metabolic disorders, with a particular emphasis on obesity, which affects over 17% of adults in Europe and significantly contributes to metabolic and cardiovascular diseases. The conference aimed to advance the understanding of metabolism and its implications for human health by adopting a holistic approach to address the multifaceted problem of metabolic syndrome. A key focus was on exploring the interactions among organs and their roles in metabolic dysfunction.

The workshop featured sessions on:

Adipocyte Biology: Discussing advancements that reveal the diverse functions of adipose tissue beyond fat storage.
Liver Metabolism and Nutrient Signaling: Exploring exciting discoveries in liver metabolism, nutrient signaling, exercise, and their impact on metabolic diseases.
Mitochondrial Bioenergetics: Examining the role of mitochondrial bioenergetics in metabolic regulation, offering potential therapeutic opportunities.
Heart Disease in Metabolic Dysfunction: Spotlighting heart disease within the context of metabolic dysfunction.

Through interdisciplinary collaboration, the conference aimed to provide a comprehensive understanding of metabolic disorders and identify innovative approaches to enhance their management.

Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis

13/01/2025 / Sabio lab

Beatriz Cicuéndez, Alfonso Mora, Juan Antonio López, Andrea Curtabbi, Javier Pérez-García, Begoña Porteiro, Daniel Jimenez-Blasco, Pedro Latorre-Muro, Paula Vo, Madison Jerome, Beatriz Gómez-Santos, Rafael Romero-Becerra, Magdalena Leiva, Elena Rodríguez, Marta León, Luis Leiva-Vega, Noemi Gómez-Lado, Jorge L. Torres, Lourdes Hernández-Cosido, Pablo Aguiar, Miguel Marcos, Martin Jastroch, Andreas Daiber, Patricia Aspichueta, Juan Pedro Bolaños, Jessica B. Spinelli, Pere Puigserver, José Antonio Enriquez, Jesús Vázquez, Cintia Folgueira & Guadalupe Sabio.

Obesity poses a global health challenge, demanding a deeper understanding of adipose tissue (AT) and its mitochondria. This study describes the role of the mitochondrial protein Methylation-controlled J protein (MCJ/DnaJC15) in orchestrating brown adipose tissue (BAT) thermogenesis.

Mitochondia from brown fat (Image: Beatriz Cicuéndez).

Here we show how MCJ expression decreases during obesity, as evident in human and mouse adipose tissue samples. MCJ^KO mice, even without UCP1, a fundamental thermogenic protein, exhibit elevated BAT thermogenesis. Electron microscopy unveils changes in mitochondrial morphology resembling BAT activation. Proteomic analysis confirms these findings and suggests involvement of the eIF2α mediated stress response. The pivotal role of eIF2α is scrutinized by in vivo CRISPR deletion of eIF2α in MCJ^KO mice, abrogating thermogenesis.

These findings uncover the importance of MCJ as a regulator of BAT thermogenesis, presenting it as a promising target for obesity therapy.

Nat Commun (2025); 16: 229.