Sabio lab

at the CNIC

Tag: neutrophils

María Crespo awarded in the Archimedes Competition

Our lab mate María Crespo has been awarded the second prize in the Archimedes Competition. She will receive a prize of € 2,000.

María Crespo

The competition, organized by the Spanish Ministry of Education, favours the incorporation of young students into the research field by awarding them for their original Master projects of scientific or technological research. On this occasion, more than 350 students throughout Spain participated, of which only 25 went to the final.

Under the supervision of Guadalupe Sabio and Magdalena Leiva, Crespo has studied the circadian rhythm of neutrophil infiltration in the liver and the possible role that these cells play in the regulation of hepatic activity. Through the use of neutropenic mice, she has analyzed the contribution of neutrophils in the progress of non-alcoholic fatty liver disease (NAFLD).

María Crespo among other finalists of the Archimedes Competition.

p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration

Bárbara González‐Terán, Nuria Matesanz, Ivana Nikolic, María Angeles Verdugo, Vinatha Sreeramkumar, Lourdes Hernández‐Cosido, Alfonso Mora, Georgiana Crainiciuc, María Laura Sáiz, Edgar Bernardo, Luis Leiva‐Vega, Elena Rodríguez, Victor Bondía, Jorge L Torres, Sonia Perez‐Sieira, Luis Ortega, Ana Cuenda, Francisco Sanchez‐Madrid, Rubén Nogueiras, Andrés Hidalgo, Miguel Marcos & Guadalupe Sabio.

Non‐alcoholic fatty liver disease (NAFLD) is a major health problem and the main cause of liver disease in Western countries. Although NAFLD is strongly associated with obesity and insulin resistance, its pathogenesis remains poorly understood.

The disease begins with an excessive accumulation of triglycerides in the liver, which stimulates an inflammatory response. Alternative p38 mitogen‐activated kinases (p38γ and p38δ) have been shown to contribute to inflammation in different diseases. Here we demonstrate that p38δ is elevated in livers of obese patients with NAFLD and that mice lacking p38γ/δ in myeloid cells are resistant to diet‐induced fatty liver, hepatic triglyceride accumulation and glucose intolerance. This protective effect is due to defective migration of p38γ/δ‐deficient neutrophils to the damaged liver.

We further show that neutrophil infiltration in wild‐type mice contributes to steatosis development by means of inflammation and liver metabolic changes. Therefore, p38γ and p38δ in myeloid cells provide a potential target for NAFLD therapy.


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