Sabio lab

at the CNIC

Tag: obesity (page 1 of 3)

Un día en familia en el CNIC (18 November 2017)

For the sixth year in a row, the CNIC participates in the Semana de la Ciencia de Madrid.

Our laboratory, as it have been doing since 2015, organises ‘Un día en familia en el CNIC’, an activity for kids from 4 to 14 years of age. It will be held on 18 November 2017 at CNIC and includes theatre, activities and experiments to show how scientists study the human body and how we learn to keep it healthy.

Inscriptions are open until 25 October 2017 at 9:00.

Creo que ninguna pastilla podrá sustituir a una vida saludable

El grupo de investigación dirigido por Sabio, gracias a su colaboración con investigadores del Hospital Universitario de Salamanca, analizó muestras de grasa de pacientes obesos e identificó una proteína, MKK6, que está presente en mayor cantidad de lo habitual.

[read more in ABC]

The authors at the CNIC (Photo: CNIC).

MKK6 controls T3-mediated browning of white adipose tissue

Nuria Matesanz, Edgar Bernardo, Rebeca Acín-Pérez, Elisa Manieri, Sonia Pérez-Sieira, Lourdes Hernández-Cosido, Valle Montalvo-Romeral, Alfonso Mora, Elena Rodríguez, Luis Leiva-Vega, Ana Victoria Lechuga-Vieco, Jesús Ruiz-Cabello, Jorge L. Torres, María Crespo-Ruiz, Francisco Centeno, Clara V. Álvarez, Miguel Marcos, José Antonio Enríquez, Rubén Nogueiras & Guadalupe Sabio.

Increasing the thermogenic capacity of adipose tissue to enhance organismal energy expenditure is considered a promising therapeutic strategy to combat obesity. Here, we report that expression of MKK6, a p38MAPK activator, is elevated in white adipose tissue of obese individuals.

Using knockout animals and shRNA, we show that Mkk6 deletion increases energy expenditure and thermogenic capacity of white adipose tissue, protecting mice against diet-induced obesity and the development of diabetes. Deletion of Mkk6 increases T3-stimulated UCP1 expression in adipocytes, thereby increasing their thermogenic capacity. Mechanistically we demonstrate that, in white adipose tissue, p38 is activated by an alternative pathway involving AMPK, TAK and TAB.

Our results identify MKK6 in adipocytes as a potential therapeutic target to reduce obesity.

Elena Rodríguez, Alfonso Mora, Ana Victoria Lechuga-Vieco, María Crespo-Ruiz, Guadalupe Sabio, José Antonio Enríquez, Nuria Matesanz & Luis Leiva-Vega (Photo: CNIC).


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