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Tag: cancer (Page 1 of 7)

Premio de Investigación Fundación Dr. Antoni Esteve 2021

El tribunal internacional que cada dos años concede el Premio de Investigación Fundación Dr. Antoni Esteve ha considerado nuestro artículo científico p38γ is essential for cell cycle progression and liver tumorigenesis como la publicación farmacológica más importante publicada por un autor español entre 2019 y 2020.

Premio de Investigación Fundación Dr. Antoni Esteve 2021

Además, han reconocido con una mención honorífica un trabajo del grupo de Rubén Nogueiras y Luisa Seoane, y cuya primera firmante, Cintia Folgueira se encuentra ahora en nuestro grupo de investigación.

Stress kinases in the development of liver steatosis and hepatocellular carcinoma

Beatriz Cicuéndez, Irene Ruiz-Garrido, Alfonso Mora & Guadalupe Sabio.

Non-alcoholic fatty liver disease (NAFLD) is an important component of metabolic syndrome and one of the most prevalent liver diseases worldwide. This disorder is closely linked to hepatic insulin resistance, lipotoxicity, and inflammation.

p38 pathway during liver steatosis
p38 pathway during liver steatosis.

Although the mechanisms that cause steatosis and chronic liver injury in NAFLD remain unclear, a key component of this process is the activation of stress-activated kinases (SAPKs), including p38 and JNK in the liver and immune system.

This review summarizes findings which indicate that the dysregulation of stress kinases plays a fundamental role in the development of steatosis and are important players in inducing liver fibrosis. To avoid the development of steatohepatitis and liver cancer, SAPK activity must be tightly regulated not only in the hepatocytes but also in other tissues, including cells of the immune system. Possible cellular mechanisms of SAPK actions are discussed.

Stress-activated kinases signaling pathways in cancer development

Leticia Herrera-Melle, María Crespo, Magdalena Leiva & Guadalupe Sabio.

Cancer is a large group of diseases characterized by abnormal cell growth that can lead to metastasis. It is the second leading cause of death worldwide, and its incidence is expected to rise over the next decades. Stress-activated protein kinases (SAPK) are important players in its regulation. Several studies have tried to unravel their role; however, their pro-tumorigenic or anti-tumorigenic properties are sometimes controversial.

JNK control of tumor microenvironment
JNK control of tumor microenvironment.

In this review, we will discuss the main roles of the different SAPK in the control of tumor development through essential processes such as cell proliferation, apoptosis or invasiveness. We will also show the latest discoveries regarding the contribution of SAPK in shaping tumor microenvironment through the regulation of organ crosstalk and immune cell response during cancer progression.

All these studies are relevant examples of how SAPK offer new therapeutic avenues for cancer patients that may help increase their survival.

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