Sabio lab

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Tag: cancer (page 1 of 4)

Adiponectin accounts for gender differences in hepatocellular carcinoma incidence

Elisa Manieri, Leticia Herrera-Melle, Alfonso Mora, Antonia Tomás-Loba, Luis Leiva-Vega, Delia I. Fernández, Elena Rodríguez, Laura Morán, Lourdes Hernández-Cosido, Jorge L. Torres, Luisa M. Seoane, Francisco Javier Cubero, Miguel Marcos & Guadalupe Sabio.

Hepatocellular carcinoma (HCC) is the sixth most common cancer type and the fourth leading cause of cancer-related death. This cancer appears with higher incidence in men and during obesity; however, the specific mechanisms underlying this correlation are unknown.

Adiponectin accounts for gender differences in liver cancer

HCC gender differences are driven by adiponectin (Image: Leticia Herrera-Melle).

Adipose tissue, a key organ in metabolic syndrome, shows evident gender disparities in the production of adipokines. Levels of the important adipokine adiponectin decrease in men during puberty, as well as in the obese state. Here, we show that this decrease in adiponectin levels is responsible for the increased liver cancer risk in males. We found that testosterone activates the protein JNK in mouse and human adipocytes. JNK-mediated inhibition of adiponectin secretion increases liver cancer cell proliferation, since adiponectin protects against liver cancer development through the activation of AMP-activated protein kinase (AMPK) and p38α.

This study provides insight into adipose tissue to liver crosstalk and its gender relation during cancer development, having the potential to guide strategies for new cancer therapeutics

La científica Guadalupe Sabio: Estar obeso es jugar a la ruleta rusa

La científica Guadalupe Sabio, quien trabaja en el Centro Nacional de Investigaciones Cardiovasculares desde 2011, asegura que a día de hoy no hay píldoras milagro contra la obesidad y las personas que son obesas «juegan a la ruleta rusa».

[Read more in eldiario.es]

La Vanguardia – Guadalupe Sabio alerta sobre los peligros de la obesidad

Guadalupe Sabio en Vivir en Salud

Interview with Guadalupe Sabio in Radio Inter program Vivir en Salud about the research of our laboratory.

      Guadalupe Sabio en Vivir en Salud (2 de marzo de 2019) – Guadalupe Sabio

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