Un grupo del CNIO ha identificado una vía de señalización molecular entre músculo y cerebro que regula las ganas de seguir haciendo ejercicio físico y que podría servir en un futuro para diseñar fármacos como los que ya existen para el apetito.
Tag: Brain (Page 1 of 2)
Cintia Folgueira, Leticia Herrera-Melle, Juan Antonio López, Victor Galvan-Alvarez, Marcos Martin-Rincon, María Isabel Cuartero, Alicia García-Culebras, Phillip A. Dumesic, Elena Rodríguez, Luis Leiva-Vega, Marta León, Begoña Porteiro, Cristina Iglesias, Jorge L. Torres, Lourdes Hernández-Cosido, Clara Bonacasa, Miguel Marcos, María Ángeles Moro, Jesús Vázquez, Jose A. L. Calbet, Bruce M. Spiegelman, Alfonso Mora & Guadalupe Sabio.
Skeletal muscle has gained recognition as an endocrine organ releasing myokines upon contraction during physical exercise. These myokines exert both local and pleiotropic health benefits, underscoring the crucial role of muscle function in countering obesity and contributing to the overall positive effects of exercise on health.
Here, we found that exercise activates muscle p38γ, increasing locomotor activity through the secretion of interleukin-15 (IL-15). IL-15 signals in the motor cortex, stimulating locomotor activity. This activation of muscle p38γ, leading to an increase locomotor activity, plays a crucial role in reducing the risk of diabetes and liver steatosis, unveiling a vital muscle-brain communication pathway with profound clinical implications. The correlation between p38γ activation in human muscle during acute exercise and increased blood IL-15 levels highlights the potential therapeutic relevance of this pathway in treating obesity and metabolic diseases.
These findings provide valuable insights into the molecular basis of exercise-induced myokine responses promoting physical activity.
We are seeking a highly motivated candidate, who would like to start a scientific career doing their doctoral thesis working in understanding p38 kinases role in how the communiation between organs affect the metabolic. This work will be supervised by Dr. Guadalupe Sabio.
We offer incorporation to CNIC via an FPU predoctoral contract. Interested candidates will need to apply before 19 September 2023 in the following CNIC website:
METABOkines: Comunicación celular en el metabolismo: Implicación de la vía de las p38s.
PID2022-138525OB-I00
ELEGIBILITY CRITERIA
- This call is open to applicants from all nationalities holding a Master’s degree in Biomedical Sciences.
- An excellent academic record and previous research experience during their undergraduate period will be valued very positively.
- Authorship of publicacions in indexed journal will be valued very positively.
- Candidates must have a solid working knowledge of English.
