Sabio lab

at the CNIC

Tag: liver (page 1 of 2)

XL Congreso de la SEBBM (23-26 October 2017)

This year’s XL SEBBM Meeting, that will be held in Barcelona from 23 to 26 October 2017, will be the 1st FEBS3+ Joint Meeting of the French-Portuguese-Spanish Biochemical and Molecular Biology Societies Congress.

Guadalupe Sabio (CNIC, Madrid), together with Gema Medina (Universidad Rey Juan Carlos, Madrid), Mª Dolores Mayán (Instituto de Investigación Biomédica de A Coruña, INIBIC), and Sonsoles Martín (Centro de Investigaciones Biológicas, CIB, CSIC, Madrid) have organised the meeting of the working group Molecular Basis of Pathology & Clinical Biochemistry / Chemical Biology on 25 October 2017 from 15:30 to 18:00

Laboratory technician

Our group seeks a motivated lab technician with at least two years of experience in histology and genotyping.

The technician will be in charge of the preparation and staining of samples for histology and immunohistochemistry, genotyping of our mouse colony and helping the other members of the lab with their experiments.

We offer a work is an international project currently in expansion developed in an environment with a solid commitment to excellent research

Deadline: 3 October 2017

For more information and application, please visit CNIC’s website.

brown fat

H&E staining of murine brown fat (Photo: Nuria Matesanz/CNIC).

Hypothalamic AMPK-ER stress-JNK1 axis mediates the central actions of thyroid hormones on energy balance

Noelia Martínez-Sánchez, Patricia Seoane-Collazo, Cristina Contreras, Luis Varela, Joan Villarroya, Eva Rial-Pensado, Xabier Buqué, Igor Aurrekoetxea, Teresa C. Delgado, Rafael Vázquez-Martínez, Ismael González-García, Juan Roa, Andrew J. Whittle, Beatriz Gomez-Santos, Vidya Velagapudi, Y.C. Loraine Tung, Donald A. Morgan, Peter J. Voshol, Pablo B. Martínez de Morentin, Tania López-González, Laura Liñares-Pose, Francisco Gonzalez, Krishna Chatterjee, Tomás Sobrino, Gema Medina-Gómez, Roger J. Davis, Núria Casals, Matej Orešič, Anthony P. Coll, Antonio Vidal-Puig, Jens Mittag, Manuel Tena-Sempere, María M. Malagón, Carlos Diéguez, María Luz Martínez-Chantar, Patricia Aspichueta, Kamal Rahmouni, Rubén Nogueiras, Guadalupe Sabio, Francesc Villarroya & Miguel López.

Pathway proposed to modulate lipid metabolism in liverThyroid hormones (THs) act in the brain to modulate energy balance. We show that central triiodothyronine (T3) regulates de novo lipogenesis in liver and lipid oxidation in brown adipose tissue (BAT) through the parasympathetic (PSNS) and sympathetic nervous system (SNS), respectively. Central T3 promotes hepatic lipogenesis with parallel stimulation of the thermogenic program in BAT.

The action of T3 depends on AMP-activated protein kinase (AMPK)-induced regulation of two signaling pathways in the ventromedial nucleus of the hypothalamus (VMH): decreased ceramide-induced endoplasmic reticulum (ER) stress, which promotes BAT thermogenesis, and increased c-Jun N-terminal kinase (JNK) activation, which controls hepatic lipid metabolism. Of note, ablation of AMPKα1 in steroidogenic factor 1 (SF1) neurons of the VMH fully recapitulated the effect of central T3, pointing to this population in mediating the effect of central THs on metabolism.

Overall, these findings uncover the underlying pathways through which central T3 modulates peripheral metabolism.


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