at the CNIC

Tag: brown adipose tissue (Page 1 of 5)

Targeting ERK3/MK5 complex for treatment of obesity and diabetes

Angel Loza-Valdes, Rabih El-Merahbi, Toufic Kassouf, Agnieszka Demczuk, Saskia Reuter, Jonathan Trujillo Viera, Till Karwen, Minhe Noh, Mona C. Löffler, Rafael Romero-Becerra, Jorge L. Torres, Miguel Marcos, Guadalupe Sabio, Urszula Wojda & Grzegorz Sumar.

Kinases represent one of the largest druggable families of proteins. Importantly, many kinases are aberrantly activated/de-activated in multiple organs during obesity, which contributes to the development of diabetes and associated diseases. Previous results indicate that the complex between Extracellular-regulated kinase 3 (ERK3) and Mitogen-Activated Protein Kinase (MAPK)-activated protein kinase 5 (MK5) suppresses energy dissipation and promotes fatty acids (FAs) output in adipose tissue and, therefore promotes obesity and diabetes. However, the therapeutic potential of targeting this complex at the systemic level has not been fully explored.

MK5 mRNA levels in subcutaneous adipose tissue in healthy lean subjects obese subjects.

Here we applied a translational approach to target the ERK3/MK5 complex in mice. Importantly, deletion of ERK3 in the whole body or administration of MK5-specific inhibitor protects against obesity and promotes insulin sensitivity. Finally, we show that the expression of ERK3 and MK5 correlates with the degree of obesity and that ERK3/MK5 complex regulates energy dissipation in human adipocytes.

Altogether, we demonstrate that ERK3/MK5 complex can be targeted in vivo to preserve metabolic health and combat obesity and diabetes.

Uncovering the role of p38 family members in adipose tissue physiology

Magdalena Leiva, Nuria Matesanz, Marta Pulgarín-Alfaro, Ivana Nikolić & Guadalupe Sabio.

The complex functions of adipose tissue have been a focus of research interest over the past twenty years. Adipose tissue is not only the main energy storage depot, but also one of the largest endocrine organs in the body and carries out crucial metabolic functions. Moreover, brown and beige adipose depots are major sites of energy expenditure through the activation of adaptive, non-shivering thermogenesis.

p38-mediated adipose tissue secretome
The p38-mediated adipose tissue secretome.

In recent years, numerous signaling molecules and pathways have emerged as critical regulators of adipose tissue, in both homeostasis and obesity-related disease. Among the best characterized are members of the p38 kinase family. The activity of these kinases has emerged as a key contributor to the biology of the white and brown adipose tissues, and their modulation could provide new therapeutic approaches against obesity.

Here, we give an overview of the roles of the distinct p38 family members in adipose tissue, focusing on their actions in adipogenesis, thermogenic activity, and secretory function.

Guadalupe Sabio defiende en la UCLM el papel de la grasa como órgano endocrino

La investigadora del Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) Guadalupe Sabio Buzo ha visitado este lunes la Universidad de Castilla-La Mancha (UCLM) para ofrecer la charla ‘Lo que la grasa esconde’ en el marco de la celebración institucional del Día Internacional de la Mujer y de la Niña en la Ciencia.

En su intervención ante estudiantes y profesores del campus toledano, explicó qué hace la grasa y cuál es su relación con enfermedades como el cáncer hepático y la diabetes y subrayó su papel como un órgano endocrino más.

[leer más en Noticias UCLM]

Guadalupe Sabio acompañada por el vicerrector de Investigación y Política Científica, Julián Garde (Foto: Gabinete de comunicación de la UCLM).
« Older posts

© 2022 Sabio lab

Theme by Anders NorénUp ↑