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Tag: white adipose tissue (page 1 of 4)

Guadalupe Sabio defiende en la UCLM el papel de la grasa como órgano endocrino

La investigadora del Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) Guadalupe Sabio Buzo ha visitado este lunes la Universidad de Castilla-La Mancha (UCLM) para ofrecer la charla ‘Lo que la grasa esconde’ en el marco de la celebración institucional del Día Internacional de la Mujer y de la Niña en la Ciencia.

En su intervención ante estudiantes y profesores del campus toledano, explicó qué hace la grasa y cuál es su relación con enfermedades como el cáncer hepático y la diabetes y subrayó su papel como un órgano endocrino más.

[leer más en Noticias UCLM]

Guadalupe Sabio acompañada por el vicerrector de Investigación y Política Científica, Julián Garde (Foto: Gabinete de comunicación de la UCLM).

Lo que la grasa esconde (18 February 2019)

As part of the celebration of the International Day of Women and Girls in Science, Guadalupe Sabio is talking on 18 February 2019 at the Universidad de Castilla La Mancha in Toledo about the endocrine role of adipose tissue.

Guadalupe Sabio – Lo que la grasa esconde

Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity

Mona C. Löffler, Alexander E. Mayer, Jonathan Trujillo Viera, Angel Loza Valdes, Rabih El‐Merahbi, Carsten P. Ade, Till Karwen, Werner Schmitz, Anja Slotta, Manuela Erk, Sudha Janaki‐Raman, Nuria Matesanz, Jorge L. Torres, Miguel Marcos, Guadalupe Sabio, Martin Eilers, Almut Schulze, Grzegorz Sumara.

Nutrient overload in combination with decreased energy dissipation promotes obesity and diabetes. Obesity results in a hormonal imbalance, which among others activates G protein‐coupled receptors utilizing diacylglycerol (DAG) as secondary messenger. Protein kinase D1 (PKD1) is a DAG effector, which integrates multiple nutritional and hormonal inputs, but its physiological role in adipocytes is unknown.

Correlation between PKD1 and HOMA‐IR

Correlation between PKD1 expression and HOMA‐IR levels in human sWAT (Image: Nuria Matesanz).

Here, we show that PKD1 promotes lipogenesis and suppresses mitochondrial fragmentation, biogenesis, respiration, and energy dissipation in an AMP‐activated protein kinase (AMPK)‐dependent manner. Moreover, mice lacking PKD1 in adipocytes are resistant to diet‐induced obesity due to elevated energy expenditure. Beiging of adipocytes promotes energy expenditure and counteracts obesity. Consistently, deletion of PKD1 promotes expression of the β3‐adrenergic receptor (ADRB3) in a CCAAT/enhancer binding protein (C/EBP)‐α‐ and δ‐dependent manner, which leads to the elevated expression of beige markers in adipocytes and subcutaneous adipose tissue. Finally, deletion of PKD1 in adipocytes improves insulin sensitivity and ameliorates liver steatosis.

Our results showed that p38δ is activated in BAT by cold exposure, and lack of this kinase specifically in adipose tissue (p38δFab-KO) resulted in overweight together with reduced energy expenditure and lower body and skin surface temperature in the BAT region. These observations indicate that p38α probably blocks BAT thermogenesis through p38δ inhibition. Consistent with the results obtained in animals, p38α was reduced in visceral and subcutaneous adipose tissue of subjects with obesity and was inversely correlated with body mass index (BMI).

Thus, depletion of PKD1 in adipocytes increases energy dissipation by several complementary mechanisms and might represent an attractive strategy to treat obesity and its related complications.

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