Tag: white adipose tissue (Page 1 of 10)

Metabolism and Cancer meeting (20-22 May 2026)

09/04/2026 / Sabio lab

Registration for the CNIO CaixaResearch Frontiers Meeting Metabolism and Cancer: Insights from Obesity and Beyond is open until 5 May 2026.

Application form

Held at CNIO Auditoriom from 20 to 22 may 2026, the meeting will highlight key drivers stemming from unhealthy metabolism that impact cancer development. It will delve into cutting-edge topics such as advancements in adipocyte biology, uncovering the diverse roles of adipose tissue beyond fat storage and its influence on tumor metabolism. Additionally, groundbreaking research on exercise and its potential impact on cancer will be presented. The role of mitochondrial bioenergetics in metabolic regulation will be rigorously examined, offering promising avenues for cancer therapy.

Moreover, the conference will scrutinize the tumor microenvironment and metabolic changes in surrounding tissues, alongside immune modulation,
particularly in the context of obesity. Cachexia, a complex syndrome involving muscle wasting and its relationship with cancer, will also be a focal point.

Preliminary Programme

Lo que la grasa esconde (20 Mar 2025)

19/03/2025 / Sabio lab

Dentro del Máster de Biología Molecular y Biotecnología de la Universidad de Murcia, Guadalupe Sabio hablará de la relevancia de la obesidad en el desarrollo de otras enfermedades, como cáncer, diabetes y enfermedades cardiovasculares.

Plasma membrane remodeling determines adipocyte expansion and mechanical adaptability

03/12/2024 / Sabio lab

María C M Aboy-Pardal, Marta C Guadamillas, Carlos R Guerrero, Mauro Català-Montoro, Mónica Toledano-Donado, Sara Terrés-Domínguez, Dácil M Pavón, Víctor Jiménez-Jiménez, Daniel Jimenez-Carretero, Moreno Zamai, Cintia Folgueira, Ana Cerezo, Fidel-Nicolás Lolo, Rubén Nogueiras, Guadalupe Sabio, Miguel Sánchez-Álvarez, Asier Echarri, Ricardo Garcia & Miguel A Del Pozo.

Adipocytes expand massively to accommodate excess energy stores and protect the organism from lipotoxicity. Adipose tissue expandability is at the center of disorders such as obesity and lipodystrophy; however, little is known about the relevance of adipocyte biomechanics on the etiology of these conditions.

Adipocyte classification based on the existence (magenta, asterisks) or absence (yellow, triangles) of surrounding collagen.

Here, we show in male mice in vivo that the adipocyte plasma membrane undergoes caveolar domain reorganization upon lipid droplet expansion. As the lipid droplet grows, caveolae disassemble to release their membrane reservoir and increase cell surface area, and transfer specific caveolar components to the LD surface. Adipose tissue null for caveolae is stiffer, shows compromised deformability, and is prone to rupture under mechanical compression. Mechanistically, phosphoacceptor Cav1 Tyr14 is required for caveolae disassembly: adipocytes bearing a Tyr14Phe mutation at this residue are stiffer and smaller, leading to decreased adiposity in vivo; exhibit deficient transfer of Cav1 and EHD2 to the LD surface, and show distinct Cav1 molecular dynamics and tension adaptation.

These results indicate that Cav1 phosphoregulation modulates caveolar dynamics as a relevant component of the homeostatic mechanoadaptation of the differentiated adipocyte.

Nat Commun (2024); 15 (1): 10102.