Los dos proyectos científicos que ofrecemos este año son:
Stress in the brain, metabolic effects: Obesity has become a new pandemic. It is known that obesity induces molecular changes in the brain that are fundamental for the development of diseases and for maintaining excess energy intake. However, little is known about how these changes appear and the molecular mechanisms that mediate them. We will study how modulating stress in the central nervous system induced by high fat diet affects the development of cardiometabolic diseases. For this purpose, genetically modified animals will be used and whole organism metabolism will be evaluated, and how the signalling of this stress in the brain affects the response of distant organs through inter-tissue communication.
Role of adipose tissue controling whole body homeostasis: Cardiometabolic diseases (CMDs)—e.g., diabetes, steatohepatitis, and cardiomyopathy— are the leading cause of death worldwide. Adipose tissue (AT) heterogeneity and dysfunction might be involved in the CMD pathogenesis. We have recently demonstrated that i) AT regulates whole-body metabolism independently of obesity and predisposes to hepatic cancer in mice and humans; and ii) molecules secreted by AT trigger liver steatosis and insulin resistance. Our studies suggest that dysfunctional AT communicates with other organs and induces pathogenic adaptive responses through evolutionarily conserved mechanisms (rodent to humans). Our preliminary results show that AT dysfunction caused by mitochondrial alteration induces cardiomyopathy in lean mice, reinforcing that AT has a central role in controlling heart functionality.
We are seeking a highly motivated candidate, who would like to start a scientific career doing their doctoral thesis working in understanding the molecular mechanisms involved in how metabolic alterations can affect the cardiac disease, focusing on cardiac metabolism and how the rest of the organs affect it. This work will be supervised by Dr. Guadalupe Sabio.
We offer incorporation to CNIC via an FPU predoctoral contract (FPU 2021 call).
This call is open to applicants from all nationalities holding a Master’s degree in Biomedical Sciences and an academic record with average grade over 8,7 (out of 10).
An excellent academic record and previous research experience during their undergraduate period will be valued very positively.
Authorship of publicacions in indexed journal will be valued very positively.
Candidates must have a solid working knowledge of English.
If you are interested, please send your CV, academic record, a letter of interest and contact details of previous references to Laura Grau (firstname.lastname@example.org) indicating in the subject: “FPU2021 Guadalupe Sabio’s lab” no later than December 7th 2021.
Interested candidates will also need to apply officially throught the official governmental application for this predoctoral program (additional information: FPU 2021 call ).