at the CNIO
El próximo jueves 13 de diciembre de 2018 tendrá lugar la segunda reunión científica del consorcio Immunothercan-CM, en el Centro Nacional de Biotecnología (Campus Universidad Autónoma).
En esta reunión, los investigadores pre y postdoctorales de los distintos grupos presentarán los últimos avances en los proyectos que se desarrollan en el marco del consorcio. Además, se discutirán aspectos que fomenten la colaboración entre los grupos.
Programa de la II reunión científica Immunothercan-CM
El grupo de investigación dirigido por Sabio, gracias a su colaboración con investigadores del Hospital Universitario de Salamanca, analizó muestras de grasa de pacientes obesos e identificó una proteína, MKK6, que está presente en mayor cantidad de lo habitual.
[read more in ABC]
The authors at the CNIC (Photo: CNIC).
Nuria Matesanz, Edgar Bernardo, Rebeca Acín-Pérez, Elisa Manieri, Sonia Pérez-Sieira, Lourdes Hernández-Cosido, Valle Montalvo-Romeral, Alfonso Mora, Elena Rodríguez, Luis Leiva-Vega, Ana Victoria Lechuga-Vieco, Jesús Ruiz-Cabello, Jorge L. Torres, María Crespo-Ruiz, Francisco Centeno, Clara V. Álvarez, Miguel Marcos, José Antonio Enríquez, Rubén Nogueiras & Guadalupe Sabio.
Measure of the thermogenic capacity of brown adipose tissue (Image: Nuria Matesanz)
Increasing the thermogenic capacity of adipose tissue to enhance organismal energy expenditure is considered a promising therapeutic strategy to combat obesity. Here, we report that expression of MKK6, a p38MAPK activator, is elevated in white adipose tissue of obese individuals.
Using knockout animals and shRNA, we show that Mkk6 deletion increases energy expenditure and thermogenic capacity of white adipose tissue, protecting mice against diet-induced obesity and the development of diabetes. Deletion of Mkk6 increases T3-stimulated UCP1 expression in adipocytes, thereby increasing their thermogenic capacity. Mechanistically we demonstrate that, in white adipose tissue, p38 is activated by an alternative pathway involving AMPK, TAK and TAB.
Our results identify MKK6 in adipocytes as a potential therapeutic target to reduce obesity.
Elena Rodríguez, Alfonso Mora, Ana Victoria Lechuga-Vieco, María Crespo-Ruiz, Guadalupe Sabio, José Antonio Enríquez, Nuria Matesanz & Luis Leiva-Vega (Photo: CNIC).
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