Sabio lab

at the CNIC

Author: Sabio lab (page 2 of 20)

El CNIC se acerca al cole (Monesterio)

El viernes 3 de mayo de 2019 estuvimos en Monesterio (Badajoz). Por la mañana entrevistaron a Guadalupe Sabio y a Alfonso Mora en la Radio Escuela del CEIP El LLano y por la tarde hicimos una serie de talleres científicos en la Casa de la Cultura para niños de infantil y primaria.

Midiendo el pH con rojo fenol.

Midiendo el pH con rojo fenol.

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F-STEAM Plasencia 2019

Nuestro laboratorio participa del 29 de abril al 2 de mayo en la feria científica F-STEAM Plasencia con ocho talleres, una práctica y una conferencia a cargo de Guadalupe Sabio.

Adiponectin accounts for gender differences in hepatocellular carcinoma incidence

Elisa Manieri, Leticia Herrera-Melle, Alfonso Mora, Antonia Tomás-Loba, Luis Leiva-Vega, Delia I. Fernández, Elena Rodríguez, Laura Morán, Lourdes Hernández-Cosido, Jorge L. Torres, Luisa M. Seoane, Francisco Javier Cubero, Miguel Marcos & Guadalupe Sabio.

Hepatocellular carcinoma (HCC) is the sixth most common cancer type and the fourth leading cause of cancer-related death. This cancer appears with higher incidence in men and during obesity; however, the specific mechanisms underlying this correlation are unknown.

Adiponectin accounts for gender differences in liver cancer

HCC gender differences are driven by adiponectin (Image: Leticia Herrera-Melle).

Adipose tissue, a key organ in metabolic syndrome, shows evident gender disparities in the production of adipokines. Levels of the important adipokine adiponectin decrease in men during puberty, as well as in the obese state. Here, we show that this decrease in adiponectin levels is responsible for the increased liver cancer risk in males. We found that testosterone activates the protein JNK in mouse and human adipocytes. JNK-mediated inhibition of adiponectin secretion increases liver cancer cell proliferation, since adiponectin protects against liver cancer development through the activation of AMP-activated protein kinase (AMPK) and p38α.

This study provides insight into adipose tissue to liver crosstalk and its gender relation during cancer development, having the potential to guide strategies for new cancer therapeutics

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